Scientific Research on Ionized Water

Research on Oxidative Stress Reduction

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body. It is a root cause of cellular aging and a contributing factor to dozens of chronic diseases. Ionized alkaline water, produced through electrolysis, carries a negative oxidation-reduction potential (ORP) — meaning it can donate electrons to neutralize free radicals.

Laboratory studies using erythrocyte sedimentation rate (ESR) and DPPH radical scavenging assays have confirmed the antioxidant capacity of electrolyzed reduced water (ERW). A key study published in Cytotechnology (2009) demonstrated that ERW protected human peripheral blood lymphocytes from hydrogen peroxide-induced damage, indicating real-world antioxidant efficacy at the cellular level.

Scientific Studies on Electrolyzed Reduced Water

Electrolyzed Reduced Water (ERW) is generated at the cathode during the electrolysis of water. It is characterized by a high pH (8.5–10.0), a negative ORP, dissolved molecular hydrogen (H₂), and active hydrogen species. These properties make ERW biologically distinct from both plain tap water and standard alkaline mineral water.

Research teams at Shiga University of Medical Science in Japan have conducted extensive studies on ERW. Their findings, published in peer-reviewed journals, show that ERW suppresses oxidative damage to DNA and cellular proteins. A 2004 study led by Professor Shirahata found that ERW contained platinum nanoparticles and dissolved hydrogen — both known antioxidant agents — which explains its superior ROS-scavenging capacity compared to conventional water.

Body pH Balance and Acid-Base Homeostasis

The human body maintains blood pH within an extremely narrow range of 7.35–7.45. Deviation beyond this range — even by 0.1 pH units — can have severe physiological consequences. The body relies on three main buffer systems: the bicarbonate buffer, the phosphate buffer, and the protein buffer system.

Dietary patterns in modern society — high in processed foods, red meat, and refined sugars — tend to produce an acidic ash, which the body must continuously work to neutralize. Research published in the European Journal of Nutrition suggests that a diet promoting net acid excretion may lead to increased risk of kidney stones, osteoporosis, and chronic kidney disease. Alkaline ionized water can serve as a dietary alkaline load that reduces the burden on these buffer systems.

Research on Chronic Disease Prevention

A growing body of epidemiological and experimental evidence links chronic low-grade acidosis to the development and progression of several diseases, including metabolic syndrome, cardiovascular disease, and certain cancers. Ionized alkaline water, by helping the body maintain acid-base balance, may play a role in the prevention of these conditions.

Specifically, research on gastroesophageal reflux disease (GERD) showed that water with a pH of 8.8 effectively and instantly neutralized pepsin — the enzyme implicated in tissue damage in GERD — while standard tap water did not. This finding, published in The Annals of Otology, Rhinology & Laryngology (2012), is among the strongest evidence for a specific clinical application of alkaline water.

Selective Antioxidant

Neutralizes only harmful free radicals, preserving beneficial ROS

Cellular Penetration

Reaches mitochondria and nuclei where damage occurs

Anti-Inflammatory

Modulates inflammatory cytokines without immune suppression

Neuroprotective

Crosses the blood-brain barrier to protect neural tissue